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毛斐
发布时间：2018-10-22   访问次数:7549   作者:毛斐





毛斐，博士，副教授

地址：梅陇路130号实验18楼431室

Email：maofei@ecust.edu.cn

 

个人简介

2014年6月毕业于中山大学威廉希尔药物化学专业，获博士学位，后进入英国威廉希尔公司从事博士后研究，合作导师为李剑教授。2016年10月出站后留校工作，从事药物化学教学和科研工作，2018年9月晋升副教授。

作为项目负责人，先后主持国家自然科学基金青年基金1项、面上项目1项、上海市自然科学基金面上项目1项、博士后科学基金（面上一等资助）1项、教育部高校基本科研业务费1项；2017年入选上海市“青年科技英才扬帆计划”；2018年入选williamhill官网“青年英才培育计划”A类；作为研究骨干参与国家新药创制重大专项1项，国家重点研发计划课题1项。

迄今已在国内外重要刊物如J. Med. Chem.; Eur. J. Med. Chem.; ACS Chem. Neurosci.等上发表SCI论文50余篇；申请发明专利20项（授权11项）；参编论著1部（药物结构优化——设计策略和经验规则）。


教育经历

2009.9 – 2014.6，中山大学，威廉希尔，药物化学，博士；

2005.8 – 2009.6，沈阳药科大学，制药工程学院，应用化学，学士。

工作经历

2018.9 – 至今，williamhill官网，威廉希尔，副教授；

2016.11 – 2018.8，williamhill官网，威廉希尔，讲师；

2014.7 – 2016.10，williamhill官网，威廉希尔，团队博士后。

  

主要研究方向

  1. 抗肿瘤创新药物开发研究

  2. 多靶点抗AD创新药物发现研究

  3. 抗耐药菌创新药物开发研究

  4. 老药二次开发研究  

  

代表性论文 (#共同第一作者，*为通讯作者)

  1.   Linghao Hu#, Hongxuan Feng#,Hongguang Zhang, Songda Yu, Qinyuan Zhao, Wei Wang, Fengxia Bao, Xun Ding, Jiajing Hu, Manjiong Wang, Yixiang Xu, Zengrui Wu, Xiaokang Li, Yun Tang, Fei Mao*, Xiaoyan Chen, Haiyan Zhang*, Jian Li*. Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents. J. Med. Chem. 2020, 63, 1051-1067.

  2.  Yang Chen#, Yunxia Cui#, Xiao Sun#, Huiwen Wu, Manjiao Ou, Yunzhe Tang, Shuaishuai Ni, Xiaokang Li, Jin Zhu, Fei Mao*, Yudong Wang* and Jian Li*. Repurposing of antipsychotics perphenazine for the treatment of endometrial cancer. Bioorg. Med. Chem Lett. 2020, 30, 127239.

  3. Wenwen Liu#, Huan Wang#, Xiaokang Li#, Yixiang Xu, Jian Zhang, Wei Wang, Qi Gong, Xiaoxia Qiu, Jin Zhu, Fei Mao*, Haiyan Zhang*, Jian Li*. Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment. Bioorg. Med. Chem. 2018, 26, 3117–3125.

  4. Wei Ni#, Huan Wang#, Xiaokang Li#, Xinyu Zheng#, Manjiong Wang, Jian Zhang, Qi Gong, Dazheng Ling, Fei Mao*, Haiyan Zhang*, Jian Li*. Novel tadalafil derivatives ameliorates scopolamine-induced cognitive impairment in mice via inhibition of acetylcholinesterase (AChE) and phosphodiesterase 5 (PDE5). ACS Chem. Neurosci. 2018, 9, 1625–1636.

  5. Baoli Li#, Shuaishuai Ni#, Fei Mao#, Feifei Chen, Yifu Liu, Hanwen Wei, Wenhua Chen, Jin Zhu, Lefu Lan*, Jian Li*. Novel terminal bipheny-based diapophytoene desaturases (CrtN) inhibitors as anti-MRSA/VISR/LRSA agents with reduced hERG activity. J. Med. Chem. 2018, 61, 224–250.

  6. Fei Mao#, Huan Wang#, Wei Ni#, Xinyu Zheng, Manjiong Wang, Keting Bao, Dazheng Ling, Xiaokang Li, Yixiang Xu, Haiyan Zhang*, Jian Li*. Design, synthesis, and biological evaluation of orally available first-generation dual-target selective inhibitors of acetylcholinesterase (AChE) and phosphodiesterase 5 (PDE5) for the treatment of Alzheimer’s disease. ACS Chem. Neurosci. 2018, 9, 328–345.

  7. Hanwen Wei#, Fei Mao#, Shuaishuai Ni#, Feifei Chen, Baoli Li, Xiaoxia Qiu, Linghao Hu, Manjiong Wang, Xinyu Zheng, Jin Zhu, Lefu Lan*, Jian Li*. Discovery of novel piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections. Eur. J. Med. Chem. 2018, 145, 235–251.

  8. Yi-xiang Xu#, Huan Wang#, Xiao-kang Li, Sheng-nan Dong, Wen-wen Liu, Qi Gong, Tian-duan-yi Wang, Yun Tang, Jin Zhu, Jian Li*, Hai-yan Zhang*, Fei Mao*. Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease. Eur. J. Med. Chem. 2018, 143, 33–47.

  9. Xiaokang Li#, Huan Wang#, Yixiang Xu, Wenwen Liu, Xiaoxia Qiu, Jin Zhu, Fei Mao*, Haiyan Zhang*, Jian Li*. Novel vilazodone-tacrine hybrids as potential multitarget-directed ligands for the treatment of Alzheimer’s disease accompanied with depression: design, synthesis and biological evaluation. ACS Chem. Neurosci. 2017, 8, 2708–2721.

  10. Yanli Lu#, Fei Mao#, Xiaokang Li, Xinyu Zheng, Manjiong Wang, Qing Xu, Jin Zhu, and Jian Li*. Discovery of potent, selective stem cell factor receptor/platelet derived growth factor receptor alpha (c-KIT/PDGFRα) dual inhibitor for the treatment of imatinib-resistant gastrointestinal stromal tumors (GISTs). J. Med. Chem. 2017, 60, 5099–5119.

  11. Xiaokang Li#, Huan Wang#, Zhengyu Lu, Xinyu Zheng, Wei Ni, Jin Zhu, Yan Fu, Fulin Lian, Naixia Zhang, Jian Li*, Haiyan Zhang*, and Fei Mao*. Development of multifunctional pyrimidinylthiourea derivatives as potential anti-Alzheimer agents. J. Med. Chem. 2016, 59, 8326−8344.

  12. Fei Mao#, Qingya Kong#, Wei Ni, Xiang Xu, Dazheng Ling, Zhengyu Lu, Jian Li*. Melting point distribution analysis of the global approved and discontinued drugs: a Research for improving the success chance of drug design and discovery. ChemistryOpen, 2016, 5, 357–368.

  13. Fei Mao, Wei Ni, Xiang Xu, Hui Wang, Jing Wang, Min Ji, Jian Li*. Chemical structure-related drug-like criteria of global approved drugs. Molecules 2016, 21, 75; doi:10.3390/molecules21010075.

  14. Dengwei Wu#, Fei Mao#, Yan Ye, Jian Li, Chuanlian Xu*, Xiaomin Luo, Jing Chen*, Xu Shen. Policresulen as a novel inhibitor of NS2B/NS3 protease efficiently suppressed the replication of DENV2 virus. Acta Pharmacol. Sin. 2015, 36, 1126-1136.

  15. Fei Mao, Jianheng Li, Hui Wei, Ling Huang*, Xingshu Li*. Tacrine-propargylamine derivatives with improved acetylcholinesterase inhibitory activity and lower hepatotoxicity as a potential lead compound for the treatment of Alzheimer’s disease.J. Enzym. Inhib. Med. Chem.2015,30, 995-1001.

  16. Fei Mao, Jun Yan, Jian-heng Li, Yang sun, Xian Jia, Ling Huang*, Xing-shu Li*. New Multi-Target-Directed Small Molecules Against Alzheimer's Disease: a Combination of Resveratrol and Clioquinol. Org. Biomol. Chem. 2014, 12, 5936-5944.

  17. Fei Mao, Jian-wen Chen*, Qi Zhou, Zong-hua Luo, Li Huang, Xing-shu Li*. Novel tacrine–ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity. Bioorg. Med. Chem. Lett.2013, 23, 6737-6742.

  18. Fei Mao, Ling Huang, Zong-hua Luo, Anqiu Liu, Chuan-jun Lu, Zhi-yong Xie*, Xingshu Li*. O-Hydroxyl or o-amino benzylamine-tacrine hybrids: Multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-beta aggregation. Bioorgan. Med. Chem.2012, 20, 5884-5892.