梁欣 博士

副教授，硕士生导师

                                  邮箱：xin.liang@ecust.edu.cn

                               地址：上海市徐汇区梅陇路130号实验十八楼633室；

                           邮编：200237

个人简历：

2003.9-2007.6     华东理工老员工物工程专业，工学学士

2007.9-2012.3      华东理工老员工物化工专业，工学博士

2012.7-2015.5      美国埃默里大学（Emory University）Renhao Li’s Lab 博士后

2015.7-2016.8      英国威廉希尔公司，讲师

2016.9至今           英国威廉希尔公司，副教授

作为项目负责人主持国家自然科学基金，上海市自然科学基金，教育部基本科研业务费探索研究基金等。已在Journal of Hematology & Oncology，Molecular Therapy，British Journal of Cancer，Arterioscler Thromb Vasc Biol等国际SCI期刊发表论文36篇，SCI他引500余次。

研究方向：

主要研究领域为肿瘤转移以及微环境的相互作用研究。包括血小板参与肿瘤转移微环境形成的机制研究，miRNA在肿瘤转移以及微环境中的相互作用研究，小分子化合物或抗体药物的抗肿瘤机制研究。

代表性论文：

1.   Yin Q, Gu J, Qi Y, Lu Y, Yang L, Liu J*, Liang X*. ADAM28 from both endothelium and gastric cancer cleaves von Willebrand Factor to eliminate von Willebrand Factor-induced apoptosis of gastric cancer cells. Eur J Pharmacol. 2021, 898:173994.

2.      Zhao Y, Tao Q, Li S, Zheng P*, Liu J, Liang X*. Both endogenous and exogenous miR-139-5p inhibit Fusobacterium nucleatum-related colorectal cancer development. Eur J Pharmacol. 2020, 888:173459.

3.     Zhao Y, Xu J, Le V, Gong Q, Li S, Gao F, Ni L*, Liu J*, Liang X*. Epcam aptamer-functionalized cationic liposome-based nanoparticles loaded with mir-139-5p for targeted therapy in colorectal cancer. Molecular Pharmaceutics. 2019, 16(11): 4696-4710.

4.    Xu K*, Zhan Y, Yuan Z, Qiu Y, Wang H, Fan G, Wang J, Li W, Cao Y, Shen X, Zhang J, Liang X*, Yin P*. Hypoxia Induces Drug Resistance in Colorectal Cancer through the HIF-1α/miR-338-5p/IL-6 Feedback Loop. Molecular Therapy. 2019, 27(10): 1810-1824. 

5.    Qi Y, Chen W, Liang X, Xu K*, Gu X, Wu F, Fan X, Ren S, Liu J, Zhang J, Li R, Liu J*, Liang X*. Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction. Journal of Hematology & Oncology. 2018, 11(1):117.

6.    Liang X, Shi H, Yang L, Qiu C, Lin S, Qi Y, Li J*, Zhao A*, Liu J*. Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells. British Journal of Cancer. 2017, 116(7):903-911. 

7.    Liang X, Wang J, Chen W, Ma X, Wang Y, Nagao N, Weng W*, Huang J*, Liu J*. Inhibition of airway remodeling and inflammation by isoforskolin in PDGF-induced rat ASMCs and OVA-induced rat asthma model. Biomed Pharmacother. 2017, 95:275-286. 

8.    Xu K, Chen G, Li X, Wu X, Chang Z, Xu J, Zhu Y, Yin P, Liang X*, Dong L*. MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling. Sci Rep. 2017, 7:41718.   

9.     Lin S, Yang L, Shi H, Du W, Qi Y, Qiu C, Liang X*, Shi W*, Liu J*. Endoplasmic reticulum-targeting photosensitizer Hypericin confers chemo-sensitization towards oxaliplatin through inducing pro-death autophagy. Int J Biochem Cell Biol. 2017 Jun;87: 54-68. 

10.  Chen W¹, Liang X¹, Syed AK, Jessup P, Church WR, Ware J, Josephson CD, Li R*. Inhibiting GPIbα shedding preserves post-transfusion recovery and hemostatic function of platelets after prolonged storage. Arterioscler Thromb Vasc Biol. 2016, 36(9):1821-1828. 

11.   Liang X, Syed AK, Russell SR, Ware J, Li R*. Dimerization of glycoprotein Ib is not sufficient to induce platelet clearance. J Thromb Haemost. 2016,14: 381-386. 

12.  Mao R, Zou F, Yang L, Lin S, Li Y, Ma M, Yin P^*, Liang X*, Liu J*. The loss of MiR-139-5p promotes colitis-associated tumorigenesis by mediating PI3K/AKT/Wnt signaling. Int J Biochem Cell Biol. 2015, 69: 153-161. 

13.  Liang X, Russell SR, Estelle S, Jones LH, Cho S, Kahn ML, Berndt MC, Bunting ST, Ware J, Li R*. Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site. J Thromb Haemost. 2013, 11(12): 2155-2162. 

注：¹共同第一作者， ^＊通讯作者