陶黎明   教授  博士生导师

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  电话:  021-64253756

陶黎明，男，1958年生于上海，博士、教授、博士生导师，享受国务院政府特殊津贴。中国化工学会农药专业委员会委员、《农药学学报》编委、上海市优秀学科带头人等。1982年毕业于华东化工学院（现williamhill官网）生物化学专业，1987年获中国农科院昆虫生化专业硕士学位，2005年获中国科学院上海生命科学院理学博士学位。分别在1991~1992年赴日本理化学研究所、1996~1997年赴德国巴斯夫公司开展农用生物活性物质研究。先后工作于中国科学院武汉水生生物研究所、上海市农药研究所，2010年调入英国威廉希尔公司药物化工研究所工作至今。近30年来，一直从事天然产物类农药的筛选与研发，“八五” 至“十二五”期间主持和参与多项关于农药研究的国家科技攻关和科技支撑项目；参与完成“973计划”中“绿色化学农药”项目子课题研究；承担完成海洋”863计划”课题一项；承担完成上海市优秀学科带头人计划一项，获授权国内外发明专利40多项，以公司为唯一单位在国内外农药领域期刊发表论文60余篇。

  方向一:天然产物类农药的研发

  开展以微生物代谢产物类农药（农用抗生素）的发现、研究与创制等方面为主的工作。

  方向二: 农药毒理学

  聚焦农药的作用方式、作用机理及代谢机制，重点开展杀虫剂作用靶标及其对非靶标生物与环境生态的影响研究。

近三年代表性论著（2017~2020）

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[1]     Youwu Hao, Yang Zhang, Jiagao Cheng, Wenping Xu, Zhiping Xu, Jufang Gao, Liming Tao*. Adjuvant contributes Roundup's Unexpected Effects on A549 Cells. Environ. Res.2020,184, 109306

       [2]     唐宁，张阳，徐晓勇，陶黎明. 杀虫靶标发现及开发新策略展望[J]. 世界农药，2019,41(06), 17-23.

[3]     Yang Zhang^#, Wei Guo^#, Hui Chen, Jufang Gao, Zhiping Xu, Liming Tao, Zhong Li*, Wenping Xu*. Spinetoram confers its cytotoxic effects by inducing AMPK/mTOR-mediated autophagy and oxidative DNA damage. Ecotoxicol. Environ. Saf. 2019, 183, 109480.

[4]     Yang Zhang^#, Wei Guo^#, Hui Chen, Jufang Gao, Liming Tao, Zhong Li*, Wenping Xu*. The cytotoxic effects of spinetoram on human HepG2 cells by inducing DNA damage and mitochondria-associated apoptosis. Food Agric. Immunol. 2019, 30, 1020-1032.

[5]     Yang Zhang, Yangyang Fan, Jufang Gao, Wenping Xu, Zhiping Xu, Yutian Liu, Zhong Li*, Liming Tao*. A new 24-membered macrolide shows insecticidal activity against Pieris rapae potentially through induction of programmed cell death. Food Agric. Immunol. 2019, 30, 727-742.

[6]     Yang Zhang, Hui Chen, Yangyang Fan, Yun Yang, Jufang Gao, Wenping Xu, Zhiping Xu, Zhong Li*, Liming Tao*. Cytotoxic effects of bio-pesticide spinosad on human lung A549 cells.Chemosphere. 2019, 230, 182-189.

[7]     Yangyang Fan^#, Yang Zhang^#, Yutian Liu, Wenping Xu, Yun Yang, Youwu Hao, Liming Tao*. A natural product enhances apoptosis via mitochondria/caspase-mediated pathway in Hela cells.J. Cell Biochem. 2019, 120(10), 16811-16823.

[8]     Youwu Hao^#, Yang Zhang^#, Hongfei Ni, Jufang Gao, Yun Yang, Wenping Xu, Liming Tao. Evaluation of the cytotoxic effects of glyphosate herbicides in human liver, lung and nerve. J. Environ Sci. Heal, B. 2019, 54(9), 737-744.

[9]     Youwu Hao^#, Yang Zhang^#, Wenping Xu, Jufang Gao, Liming Tao*. Synergistic effects of adjuvant A-134 on the herbicidal effects of glyphosate. J. Pestic. Sci.2019,44(4), 249-254.

[10]Ping Zhang, Yang Zhang, Kuikui Liu, Bin Liu, Wenping Xu, Jufang Gao, Lei Ding, Liming Tao*. Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway. Cell Proliferat. 2019, 52(2), e12543.

[11]Youwu Hao, Wenping Xu, Jufang Gao, Yang Zhang, Yun Yang, Liming Tao*. Roundup® induced AMPK/mTOR mediated autophagy in human A549 cells. J. Agric. Food Chem.2019, 67, 11364-11372.

[12]Youwu Hao, Nan Zhang, Wenping Xu, Jufang Gao, Yang Zhang,Liming Tao*. A natural adjuvant shows the ability to improve the effectiveness of glyphosate application. J. Pestic. Sci.2019,44(2), 106-111.

[13]Youwu Hao, Hui Chen, Wenping Xu, Jufang Gao, Yun Yang, Yang Zhang, Liming Tao*. Roundup® confers cytotoxicity through DNA damage and Mitochondria-Associated apoptosis induction. Environ. Pollut. 2019,252A, 917-923.

[14]Haijing Cao, Wenjing Liu, Yuansen Chang, Hui Chen, Yang Zhang, Wenping Xu, Liming Tao*. 5′-Epi-SPA-6952A, a new insecticidal 24-membered macrolide produced by Streptomyces diastatochromogenes SSPRC-11339. Nat. Prod. Res. 2019, 33(5), 659-664.

[15]Yang Zhang, Yuansen Chang, Haijing Cao, Wenping Xu, Zhong Li, Liming Tao*. Potential threat of chlorpyrifos to human liver cells via the caspase-dependent Mitochondrial Pathways.  Food Agric. Immunol. 2018, 29, 294-305.

[16]Yun Yang, Wenjing Liu, Jian Wang, Yang Zhang, Wenping Xu, Liming Tao*. The different effects of natural pyrethrins and beta-cypermethrin on human hepatocyte QSG7701 cells by ROS-mediated oxidative damage. Environ. Sci. Pollut. R. 2018, 25(24), 24230-24240.

[17]Yun Yang, Jufang Gao,Yang Zhang, Wenping Xu, Youwu Hao, Zhiping Xu, Liming Tao*. Natural pyrethrins induce autophagy of HepG2 cells through the activation of AMPK/mTOR pathway. Environ. Pollut. 2018, 241, 1091-1097.

[18]Wenping Xu^#, Mingjun Yang^#, Jufang Gao, Yang Zhang, Liming Tao*. Oxidative stress and DNA damage induced by spinosad exposure in Spodoptera frugiperda Sf9 cells. Food Agric.Immunol. 2018, 29, 171-181.

        [19]郭俊夫，宗蜜蜜，徐文平，陶黎明*. 海洋链霉菌P10-16代谢产物的分离与鉴定[J]. 湖南农业大学学报(自然科学版)，2017, 43(06), 615-619.

       [20]陈允亮，毛慧渊，陶黎明*. 防治西瓜枯萎病的微生物菌种的筛选与鉴定[J]. 安徽农业科学，2017, 45(28), 11-13.

       [21]程亮，罗明明，吴继纲，郝有武，徐文平，陶黎明*. 海洋放线菌Y12-26中抗真菌活性代谢产物的分离纯化与结构鉴定[J]. 中国抗生素杂志，2017, 42(08), 631-638.

       [22]杨韵，卢淼青，张阳，杨明俊，徐文平，陶黎明*. 高效氯氰菊酯对草地贪夜蛾Sf9细胞自噬的诱导作用[J]. 农药学学报，2017, 19(02), 176-181.

       [23]贾敬，徐殿胜，庄秀园，张道敬*，陶黎明，李元广*. 小球藻热水提取物功能成分的活性跟踪分离[J]. 生物工程学报，2017, 33(05), 743-756.

[24]Yang Zhang, Jigang Wu, Wenping Xu, Jufang Gao, Haijing Cao, Mingjun Yang, Bo Wang, Youwu Hao, Liming Tao*. Cytotoxic effects of avermectin on human HepG2 cells in vitro bioassays. Environ. Pollut. 2017, 220, 1127-1137.

[25]Mingjun Yang, Bo Wang, Jufang Gao, Yang Zhang, Wenping Xu, Liming Tao*. Spinosad induces programmed cell death involves mitochondrial dysfunction and cytochrome c release in Spodoptera frugiperda Sf9 cells. Chemosphere. 2017, 169, 155-161.

[26]Yun Yang, Mimi Zong, Wenping Xu, Yang Zhang, Bo Wang, Mingjun Yang, Liming Tao*. Natural pyrethrins induces apoptosis in human hepatocyte cells via Bax- and Bcl-2-mediated mitochondrial pathway. Chem-Biol. Interact. 2017, 262, 38-45.

[27]Wenping Xu^#, Bo Wang^#, Mingjun Yang, Yang Zhang, Zhiping Xu, Yun Yang, Haijing Cao, Liming Tao*. Tebufenozide induces G1/S cell cycle arrest and apoptosis in human cells. Environ. Toxicol Phar. 2017, 49, 89 - 96.

[28]Youwu Hao, Gaohui Zhou, Wei Wu, Yang Zhang, Liming Tao, Jianhua Yao, Wenping Xu*. Synthesis and antiviral evaluation of novel N-6 substituted adenosine analogues. Tetrahedron Lett. 2017, 58(3), 190-193.

[29]Mingjun Yang, Youwu Hao, Jufang Gao, Yang Zhang, Wenping Xu, Liming Tao*. Spinosad induces autophagy of Spodoptera frugiperda Sf9 cells and the activation of AMPK/mTOR signaling pathway. Comp. Biochem. Physiol. C: Pharmacol. Toxicol. 2017, 195, 52-59.

[30]Wenping Xu^#, Songlin Liu^#, Yang Zhang, Jufang Gao, Mingjun Yang, Xiao Liu, Liming Tao*. Cypermethrin resistance conferred by increased target insensitivity and metabolic detoxification in Culex pipiens pallens Coq. Pestic. Biochem. Physiol. 2017, 142C, 77-82.

[31]Zhiping Xu, Miaoqing Lu, Mingjun Yang, Wenping Xu, Jufang Gao, Yang Zhang, Yun Yang, Liming Tao*. Pyrethrum-extract induced autophagy in Insect cells: A new target? Pestic. Biochem. Physiol. 2017, 137, 21-26.