余星昕 博士
副教授、硕士生导师
联系方式
邮箱：xxyu@ecust.edu.cn
传真：021-64252431
通讯地址：上海市徐汇区梅陇路130号318信箱
邮编：200237
个人简介
2012年6月获复旦大学有机化学博士学位，上海市优秀毕业生。毕业后赴美国明尼苏达大学(University of Minnesota)威廉希尔从事小分子肺癌抑制剂研发的博士后研究。2013年8月加入英国威廉希尔公司，开展药物小分子设计合成及其作用机制研究。2015年9月晋升副教授，同年被聘为硕士生导师。
作为项目负责人，主持国家自然科学基金（青年基金），主持教育部基本科研业务费探索研究基金（2项）；2014年入选上海市“浦江人才计划” 和上海市首批“青年科技英才扬帆计划”；2015年被评为williamhill官网“青年英才引进与培育计划”骨干和2015年度“威廉希尔优秀青年教师”。
已在Org. Lett.; J. Org. Chem.; Chem. Commun.; Chem. Eur. J.; Chem. Soc. Rev.等国际核心期刊上发表SCI论文40余篇，论文被引用1000余次，h指数22。获得中国发明专利授权1项。
主要研究方向
基于新技术、新方法和新反应的新型杂环化合物的设计合成，构建具有生物活性的类天然小分子化合物用于创新药物研究。
近期发表论文
1. Hua Deng,‡ Renmeng Jia,‡ Wu-Lin Yang, Xingxin Yu*, Wei-Ping Deng*. Chem. Commun., 2019, 55, 7346-7349. ([‡] equal contribution)
Ligand-controlled switch in diastereoselectivities: catalytic asymmetric construction of spirocyclic pyrrolidine-azetidine/oxe(thie)tane derivatives.
2. Jinbin Zhu, Linwei Huang, Wei Dong, Naikai Li, Xingxin Yu, Wei-Ping Deng*, Wenjun Tang*. Angew. Chem. Int. Ed., 10.1002/anie.201910008.
Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to N-Unprotected Ketimines: Efficient Synthesis of Cipargamin.
3. Renmeng Jia, Jiang Meng, Jiaying Leng, Xingxin Yu*, Wei-Ping Deng*. Chem. Asian. J., 2018, 13, 2360-2364.
Rhodium(II)-Catalyzed Reaction of 1-Tosyl-1,2,3-triazoles with Morita-Baylis-Hillman Adducts: Synthesis of 3,4-Fused Pyrroles.
4. Jiang Meng, Renmeng Jia, Jiaying Leng, Min Wen, Xingxin Yu*, Wei-Ping Deng*. Org. Lett., 2017, 19, 4520-4523.
Carbon-Carbon Bond Formation by Reaction of Rhodium Azavinylcarbenes with Secondary Amides: Access to Indigo Analogues from Isatins.
5. Jiang Meng, Min Wen, Shiwei Zhang, Peiwen Pan, Xingxin Yu*, Wei-Ping Deng*. J. Org. Chem., 2017, 82, 1676-1687. (Highlighted by Synfacts, 2017, 13, 354.)
Unexpected O-H Insertion of Rhodium-Azavinylcarbenes with N-Acylhydrazones: Divergent Synthesis of 3,6-Disubstituted- and 3,5,6-Trisubstituted-1,2,4-Triazines.
6. Jiang Meng, Xiangfeng Ding, Xingxin Yu*, Wei-Ping Deng. Tetrahedron, 2016, 72, 176-183.
Synthesis of 2,5-epoxy-1,4-benzoxazepines via rhodium(II)-catalyzed reaction of 1-tosyl-1,2,3-triazoles and salicylaldehydes.
7. Bo Zhou[+], Xingxin Yu[+], Chunlin Zhuang*, Peter Villalta, Yong Lin, Junxuan Lu, Chengguo Xing*. ChemMedChem, 2016, 11, 1436-1445. ([+] equal contribution)
Unambiguous Identification of β-Tubulin as the Direct Cellular Target Responsible for the Cytotoxicity of Chalcone by Photoaffinity Labeling.
8. Linwei Huang, Jinbin Zhu, Guangjun Jiao, Zheng Wang, Xingxin Yu, Wei-Ping Deng*, Wenjun Tang*. Angew. Chem. Int. Ed., 2016, 55, 4527-4531. (Highlighted by Synfacts, 2016, 12, 557.)
Highly Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to Simple Aryl Ketones: Efficient Synthesis of Escitalopram.
9. Fu-Sheng He, Jing-Hai Jin, Zhong-Tao Yang, Xingxin Yu, John S. Fossey, Wei-Ping Deng*. ACS Catal., 2016, 6, 652-656. (Highlighted by Synfacts, 2016, 12, 390.)
Direct Asymmetric Synthesis of β-Bis-Aryl-α-Amino Acid Esters via Enantioselective Copper-Catalyzed Addition of p-Quinone Methides.
10. Wu-Lin Yang, Chun-Yan Li, Wen-Jing Qin, Fei-Fei Tang, Xingxin Yu, Wei-Ping Deng*. ACS Catal., 2016, 6, 5685-5690. (Highlighted by Synfacts, 2016, 12, 1058.)
Cu(I)-Catalyzed Chemoselective and Stereoselective [3+3] Cycloaddition of Azomethine Ylides with 2-Indolylnitroethylenes: Facile Access to Highly Substituted Tetrahydro-γ-Carbolines.
11. Wu-Lin Yang, Fei-Fei Tang, Fu-Sheng He, Chun-Yan Li, Xingxin Yu*, Wei-Ping Deng*. Org. Lett., 2015, 17, 4822-4825. (Highlighted by Synfacts, 2015, 11, 1285.)
Asymmetric Construction of Spirocyclic Pyrrolidine-thia(oxa)zolidinediones via N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with 5-Alkylidene Thia(oxa)zolidine-2,4-diones.
12. Fu-Sheng He, Han Zhu, Zheng Wang, Ming Gao, Xingxin Yu*, Wei-Ping Deng*. Org. Lett., 2015, 17, 4988-4991. (Highlighted by Synfacts, 2015, 11, 1284.)
Asymmetric Construction of 3,4-Diamino Pyrrolidines via Chiral N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with β-Phthalimidonitroethene.
13. Zheng Wang[+], Xingxin Yu*[+], Bo-Xue Tian, Daniel T. Payne, Wu-Lin Yang, Yang-Zi Liu, John S. Fossey, Wei-Ping Deng*. Chem. Eur. J., 2015, 21, 10457-10465. ([+] equal contribution)
Chiral N,O-Ligand/Cu(OAc)2 Catalyzed Asymmetric Construction of 4-Aminopyrrolidine Derivativesvia 1,3-Dipolar Cycloaddition of Azomethine Ylides with α-phthalimidoacrylates.
14. Wu-Lin Yang, Yang-Zi Liu, Shuai Luo, Xingxin Yu*, John S. Fossey, Wei-Ping Deng*. Chem. Commun., 2015, 51, 9212-9215. (Highlighted by Synfacts, 2015, 11, 738.)
The copper-catalyzed asymmetric construction of a dispiropyrrolidine skeleton via 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides.
15. Fei-Fei Tang, Wu-Lin Yang, Xingxin Yu*, Wei-Ping Deng*. Catal. Sci. Technol., 2015, 5, 3568-3575.
Cu(OAc)2/FOXAP complex catalyzed construction of 2,5-dihydropyrrole derivatives via asymmetric 1,3-dipolar cycloaddition of azomethine ylides with ethynyl ketones.
16. Shan-Shan Jiang, Qin-Chang Xu, Ming-Yu Zhu, Xingxin Yu*, Wei-Ping Deng*. J. Org. Chem., 2015, 80, 3159-3169.
Kinetic Resolution of α-Methylene-β-hydroxy Esters Catalyzed by Acyl Transfer Catalyst An-PIQ.
17. Shan-Shan Jiang, Bo-Qi Gu, Ming-Yu Zhu, Xingxin Yu*, Wei-Ping Deng*. Tetrahedron, 2015, 71, 1187-1191.
Nonenzymatic kinetic resolution of α-aryl substituted allylic alcohols catalyzed by acyl transfer catalyst Np-PIQ.
18. Wen-Jing Qin, Yi Li, Xingxin Yu*, Wei-Ping Deng*. Tetrahedron, 2015, 71, 1182-1186.
TBAI/TBHP catalyzed direct N-acylation of sulfoximines with aldehydes.
19. Jiang Meng, Di Wu, Ying Shi, Xingxin Yu*, Wei-Ping Deng. Tetrahedron, 2015, 71, 1074-1079.
Construction of 1H-pyrrol-2-ylphosphonates via [3+2] cycloaddition of phosphate azomethine ylides with ynones.
20. Xianbo Wang, Xingxin Yu*. J. Org. Chem., 2014, 79, 7854-7860.
Silver(I) and Copper(I) Co-catalyzed Tandem Reaction of 2-Alkynylbenzaldoximes with Aldehydes or Alcohols: Approach to 4-Carboxylated Isoquinolines.
21. Shanshan Jiang, Bin Hu, Xingxin Yu*, Weiping Deng*. Chin. J. Chem., 2014, 32, 694-698.
Fc-PIP Catalyzed Asymmetric Synthesis of cis-2,3-Dihydrobenzofurans.
22. Yong Luo, Xiaolin Pan, Xingxin Yu*, Jie Wu*. Chem. Soc. Rev., 2014, 43, 834-846.
Double Carbometallation of Alkynes: An Efficient Strategy for the Construction of Polycycles.
